实用医学杂志2016，Vol.32Issue(5)：754-758,5.DOI:10.3969/j.issn.1006-5725.2016.05.020
ProGRP和NSE对小细胞肺癌的诊断及疗效评估的价值
Diagnostic and Curative Evaluation Value of ProGRP and NSE in Small Cell Lung Carcinoma
摘要
Abstract
Obejective To explore the diagnostic and curative evaluation value of gastrin-releasing pep-tide precursor (ProGRP) and neuron specific enolization enzyme (NSE) in small cell lung cancer (SCLC). Methods Sixty SCLC patients, sixty non-small cell lung cancer (NSCLC) patients and forty patients with be-nign pulmonary disease were collected fromJanuary 2014 to October 2015. The levels of serum ProGRP and NSE in all patients were determined by ELISA method and radioimmunoassay respectively then the clinical value of ProGRP and NSE on SCLC was evaluated. Results The levels of ProGRP and NSE in SCLC group were signif-icantly higher than those in NSCLC group and those in lung benign disease group (P < 0.05). The levels of Pro-GRP and NSE in extensive stage were higher than those in limited stage in SCLC group (P < 0.05). The bound-ary value of SCLC through ProGRP identified through ROC curve was 64.68 pg/mL. The diagnostic sensitivity , specific degree and Youdenindex of ProGRP in SCLC were 86.7%, 97.5% and 0.842 respectively, which were significantly higher than NSE (P < 0.05). After 2 cycles of chemotherapy, serum ProGRP in SCLC disease con-trol groupwere significantly decreased(P < 0.05) but on difference of serum ProGRP was found in SCLC progres-siongroup (P > 0.05). Conclusion ProGRP and NSE can be used as markers for the diagnostic and curative evaluation of SCLC. And ProGRP has higher sensitivity and specificity than NSE and can be promoted in clinic.关键词
小细胞肺癌/胃泌素释放肽前体/神经元特异性烯醇化酶/肿瘤标志物Key words
Small cell lung carcinoma/Pro-gastrin-releasing peptid/Neuron-specific enolase/Tu-mor markers引用本文复制引用
李德经,宁国兰,柳兆飞,张润,李殿明..ProGRP和NSE对小细胞肺癌的诊断及疗效评估的价值[J].实用医学杂志,2016,32(5):754-758,5.基金项目
国家临床重点专科建设项目基金 （）
