实用医学杂志2016，Vol.32Issue(5)：778-781,4.DOI:10.3969/j.issn.1006-5725.2016.05.027
多发性骨髓瘤患者荧光原位杂交检测遗传学异常的回顾性分析
Retrospective analysis of cytogenetic abnormalities detected by fluorescence in situ hybridization in pa-tients with multiple myeloma
摘要
Abstract
Objective To investigate the relationship of the cytogenetic abnormalities detected by FISH in patients with MM and their clinical features. Methods FISH on bone marrow (BM) cells was performed in 57 enrolled MM patients. Relationships between cytogenetic abnormalities and clinical features were analyzed. Results By statistical analysis , both D13S319 deletion and RB1 deletion were associated with high level of serum LDH (P = 0.024; P = 0.018) and BM plasma cells index (P = 0.027; P = 0.013). 1q21 amplification was significantly associated with high level of LDH (P = 0.030 ) and the occurence of light chain type myeloma (P = 0.023). IgH rearrangement was associated with renal function damage (P = 0.009). There were correlations among D13S319 deletion, RB1 deletion, 1q21 amplification and IgH rearrangement (P<0.01). Conclusion The genetic abnormalities detected by FISH in patients with MM were correlated with various clinical poor prognostic indicators, which can evaluate the condition and prognosis of patients more efficiently.关键词
多发性骨髓瘤/荧光原位杂交/细胞遗传学异常Key words
Multiple myeloma/Fluorescence in situ hybridization/Cytogenetic abnormalities引用本文复制引用
蔡可,黄红铭,马亚男,姜胜华,丁润生,陆伟,沈毅,孙中伟,吴艳..多发性骨髓瘤患者荧光原位杂交检测遗传学异常的回顾性分析[J].实用医学杂志,2016,32(5):778-781,4.基金项目
国家自然科学基金资助（国家青年科学基金）项目 （）
