特产研究2016，Vol.38Issue(1)：5-8,20,5.DOI:10.16720/j.cnki.tcyj.2016.01.002
Rg1联合B族维生素对急性心肌缺血小鼠NO释放及Rg1入脑量的影响
Effects of Rg1 and B vitamins on Improving the NO Level and Brain Concentration of Rg1 Against Acute Myocardial Ischemia in Mice
陈银彬 1王玉芳 1侯志芳 1王英平 1符洋洋 2郑培和1
作者信息
- 1. 中国农业科学院特产研究所，长春 130112
- 2. 北京理工大学生命学院，北京 100000
- 折叠
摘要
Abstract
The aim of the present study is to investigate whether ginsenoside Rg1 combined with B vitamins could increase the NO level in serum against acute myocardial ischemia in mice ,and the cooperative formation mechanism is discussed by comparing the brain concentration of Rg 1 . The ICR mice were randomly divided into five groups(ten mice in each group) .Control group ,ISO-induced model group ,Rg1 group ,B vita-mins group and combined group ,and each group was orally administered with drug for 10 consecutive days .Mouse received ISO-HCl by in-traperitoneal injection (ip) to get the acute myocardial ischemia model .At the end of the experiment ,the NO level in serum was measured by the assay kits and the brain concentration of Rg1 was detected by LC-MS/MS .These data demonstrated that the NO level in serum of the com-bined group was significantly higher than that of Rg1 group and B vitamins group(P<0.01);The brain concentration of Rg1 of combined group was significantly higher than that of Rg1 group( P<0.01);Correlative analysis indicated the NO level in serum is in highly significant positive correlation with brain concentration of Rg1 .Ginsenoside Rg1 combined with B vitamins has a synergistic enhancement effect on the NO level in serum ,and the increase of the brain concentration of Rg1 may be a way to generate the Synergy .关键词
人参皂苷Rg1/B族维生素/急性心肌缺血/协同作用Key words
ginsenoside Rg1/B vitamins/acute myocardial ischemia/synergy分类
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陈银彬,王玉芳,侯志芳,王英平,符洋洋,郑培和..Rg1联合B族维生素对急性心肌缺血小鼠NO释放及Rg1入脑量的影响[J].特产研究,2016,38(1):5-8,20,5.
