特产研究2016，Vol.38Issue(1)：27-31,52,6.DOI:10.16720/j.cnki.tcyj.2016.01.007
硅藻土在药用辅料中崩解作用的研究
Research of Diatomite Disintegrating Role in Pharmaceutical Excipients
摘要
Abstract
To study the role of diatomite as pharmaceutical excipients ,mainly study the effect of its disintegrating time on tablet and the differ-ence of disintegrating time between diatomite and common disintegration .Select prescription of Thiamazole Tablets which the disintegration time is qualified .On the basis of that ,the fillers in Thiamazole Tablets are replaced by three batches of diatomite though gradually changing the amount .Observe the effect of disintegration time on Thiamazole Tablets and compare the difference between diatomite and conventional disinte-grants ,such as CMS-Na ,PVPP ,L-HPC .Then study the effect of acidity on the disintegration time of Thiamazole Tablets which use diatomite as disintegrants .Disintegration time of tables are all within the prescribed scope when use diatomite as disintegrants .Although its speed is slower than PVPP ,it does not exist the increasing trend of disintegration time as the dosage is adding ,which is different from CMS-Na and L-HPC . At the same time ,the degree of acidity has no obvious effect on disintegration time of Diatomite -Thiamazole Tablets ( P>0.05 ) .diatomite as disintegrants can not only ensure the disintegration time of table within the prescribed scope ,but also is not affected by the acidity of solution . And the disintegration time is not obviously changed when the amount of diatomite is altered ,therefore have important research value .关键词
硅藻土/药用辅料/崩解剂/崩解时间Key words
diatomite/pharmaceutical excipients/disintegrating agent/disintegration time分类
化学化工引用本文复制引用
李佳芮,黄帮蕊,马方圆,陈宇婷,丛瑜,任象玉,金向群..硅藻土在药用辅料中崩解作用的研究[J].特产研究,2016,38(1):27-31,52,6.基金项目
吉林省科技发展计划项目 （）
