现代妇产科进展2016，Vol.25Issue(4)：277-280,4.DOI:10.13283/j.cnki.xdfckjz.2016.04.010
氯米芬联合HMG在促排卵人工授精周期中防止过早内源性黄体生成素峰的有效性研究
study of clomiphene citrate in preventing premature LH surge during controlled ovari-an stimulation in women undergoing IUI
摘要
Abstract
Objective:To study the effectiveness of clomiphene citrate combined with HMG in preventing premature LH surge during controlled ovarian stimulation in women under-going IUI. To Provide the clinical basis for the improvement of IUI pregnancy rates. Methods:A total of 144 cases from Jan. 2012 to Jan. 2015 were randomly assigned either an observation group treated with CC+HMG ( n=72 ) or a control group only treated with HMG controlled o-varian stimulation (n=72). The premature LH rates,clinical pregnancy rates,LUF rates,can-celed cycles rates,OHSS rates,multiple pregnancy rates,the day of HCG injection endometrial thickness,E2 levels,and the number of mature follicles were observed and compared. Results:Compared with the control group, the number of patients who had a premature LH surge and LUF was significantly lower in the observation group (5. 8% vs 17. 9%,8. 7% vs 20. 9%,P<0. 05). The mean E2 levels (pg/ml),the number of mature follicles and the pregnancy rates were significantly higher[(379.4±127. 8) pg/ml vs (288. 8±97. 3) pg/ml,2. 43±0. 75 vs 1. 71±0. 78,21. 7% vs 9. 0%,P<0. 05). There was no significant difference in cancellation, endometrial thickness, OHSS rates and multiple pregnancy rates. Conclusions:During the process of COS/IUI in unknown reason infertility,CC combined with HMG has been proven to be effective in reducing premature LH surges,and able to improve the pregnancy rates.关键词
氯米芬/COS/过早LH峰/IUIKey words
CC/COS/Premature LH surge/IUI分类
医药卫生引用本文复制引用
方玉,陈红,陈洁瑛,林华丽..氯米芬联合HMG在促排卵人工授精周期中防止过早内源性黄体生成素峰的有效性研究[J].现代妇产科进展,2016,25(4):277-280,4.基金项目
衢州市科技局项目基金(No:20091092) （No:20091092）
