中国组织工程研究2016，Vol.20Issue(5)：754-759,6.DOI:10.3969/j.issn.2095-4344.2016.05.025
构建骨质疏松动物模型建模方法的改进及评价
Improvement and evaluation of modeling method in animal models of osteoporosis
摘要
Abstract
BACKGROUND:Animal models of osteoporosis play an important role in the research of the pathogenesis, occurrence and development of osteoporosis, as wel as in the clinical diagnosis, prevention and treatment of osteoporosis. OBJECTIVE: To summarize and discuss the establishment and research ideas of osteoporosis models, explore the current situation and advance of osteoporosis models, compare the advantages and disadvantages of various methods, and provide evidence for clinical investigation. METHODS: A computer-based online search was conducted in SinoMed, VIP, Wanfang and PubMed databases by using the key words of “animal model, osteoporosis” from January 1969 to October 2015. The language was limited to both Chinese and English. Relevant articles were screened according to inclusion and exclusion criteria. The documents about the methods of osteoporosis model preparation, method improvement as wel as their advantage and disadvantage were summarized. RESULTS AND CONCLUSION:A total of 576 articles were included. Among them, articles published earlier, duplicated, and similarly were excluded, and 53 articles were finaly included. Various animal models of osteoporosis may only focus on the certain causes, certain stage, some of the main symptoms and some pathophysiological changes of disease. Accordingly, appropriate modeling methods and experimental animals should be selected based on research objective. Rat undergoing castration is the most commonly used model in the modeling of osteoporosis. Among drug methods for constructing osteoporosis model, glucocorticoids is the most commonly used one. Disuse method and nutritional method have limitations, and always combined with castration and drug methods. The effects of gene transfer, gene mutation and brain-derived model deserve关键词
实验动物/骨软骨损伤与修复动物模型/骨质疏松/建模方法/去势/药物性骨质疏松/失用性骨质疏松/营养性骨质疏松/脑源性骨质疏松/转基因小鼠/国家自然科学基金分类
医药卫生引用本文复制引用
张春丽,李忠海,周颖,刘彦,侯树勋..构建骨质疏松动物模型建模方法的改进及评价[J].中国组织工程研究,2016,20(5):754-759,6.基金项目
Tissue Engineering （）
Animals （）
Osteoporosis @@@@ the National Natural Science Foundation of China, No.81201380 （）
a Special Financial Grant from China Postdoctoral Science Foundation, No.2015T81101 （）
the Natural Science Foundation of Beijing City, No.7153174 （）
