中国组织工程研究2016，Vol.20Issue(7)：1037-1043,7.DOI:10.3969/j.issn.2095-4344.2016.07.018
组织工程化软骨修复运动性软骨损伤
Tissue-engineered cartilage for repair of sports-induced cartilage injury
摘要
Abstract
BACKGROUND:Sports-induced cartilage injury is very common; due to the poor self-healing capacity of the cartilage, cartilage repair has always been a difficult problem. <br> OBJECTIVE: To review the features of different seed cels in tissue-engineered cartilage construction and to explore the application of tissue-engineered cartilage construction in the repair of sports-induced cartilage injuryin vitro. <br> METHODS:We searched PubMed database, Wanfang database and CNKI database for articles related to tissue-engineered cartilage repair of sports-induced cartilage injuries, as wel as stem cels and scaffold materials used in tissue-engineered cartilage construction. Totaly 190 articles were retrieved, and finaly 47 articles were included in result analysis after repetitive studies were excluded. <br> RESULTS AND CONCLUSION: Bone marrow mesenchymal stem cels under different conditions can differentiate into chondrocytes, and have better potential of chondrogenic differentiation compared with adipose-derived mesenchymal stem cels and umbilical cord-derived mesenchymal stem cels. But, their safety stil needs to be further studied. Good scaffolds cannot only induce stem cel differentiation, but also be the key to cartilage construction. Composite materials are the future direction of the scaffold research.关键词
组织构建/软骨组织工程/运动性软骨损伤/组织工程软骨/软骨缺损/软骨细胞/支架材料分类
医药卫生引用本文复制引用
王大鹏,张岚,赵娜..组织工程化软骨修复运动性软骨损伤[J].中国组织工程研究,2016,20(7):1037-1043,7.基金项目
沈阳药科大学中青年教师事业发展支持计划资助课题，沈药大组人字【2014】9号文件Funding：the Career Development Supporting Plan for Young and Middle-Aged Teachers in Shenyang Pharmaceutical University, No.(2014)9 （2014）
