现代医药卫生2016，Vol.32Issue(6)：845-846,849,3.DOI:10.3969/j.issn.1009-5519.2016.06.015
幽门螺杆菌感染对胃癌患者血浆氧化抗氧化状态及胃癌组织hOGG1 mRNA表达水平的影响
Influence of Helicobacter pylori infection on plasma oxidation and antioxidant status and gastric cancer tissue hOGG1 mRNA expression level in gastric cancer patients
黄卫红 1陈亮 1宋海娟1
作者信息
- 1. 启东市第三人民医院内科，江苏南通226200
- 折叠
摘要
Abstract
Objective To study the influence of Helicobacter pylori (Hp) infection on the plasma oxidation and antioxi-dant status in the patients with gastric cancer. Methods Totally 168 cases of definitely diagnosed gastric cancer from September 2013 to June 2015 were divided into the infection group(98 cases) and non-infection group(70 cases) according to whether having Hp infection. The levels of plasma oxidant and antioxidant indexes,8-hydroxydeoxyguanosine(8-OHdG) and gastric cancer tissue human 8-hydroxyguanine DNA-glycosylase 1(hOGG1)mRNA expression were detected. Results The levels of plasma myeloper-oxidase(MPO),xanthine oxidase(XOD),malondialdehyde(MDA) and 8-OHdG,and hOGG1 mRNA relative expression amount in the infection group were higher than those in the non-infection group,while the levels of super oxide dismutase (SOD),glu-tathione peroxidase (GSH-PX) and total antioxidation capacity (T-AOC) in the infection group were lower than those in the non-in-fection group,the differences were statistically significant(P<0.05). Conclusion Hp infection could lead to the oxidant and an-tioxidant dysequilibrium more obvious,moreover aggravates the DNA damage.关键词
螺杆菌,幽门/胃肿瘤/氧化/抗氧化/8-羟基鸟嘌呤糖苷酶Key words
Helicobacter pylori/Stomach neoplasm/Oxidant/Antioxidant/Human 8-hydroxyguanine DNA-glycosylase 1引用本文复制引用
黄卫红,陈亮,宋海娟..幽门螺杆菌感染对胃癌患者血浆氧化抗氧化状态及胃癌组织hOGG1 mRNA表达水平的影响[J].现代医药卫生,2016,32(6):845-846,849,3.
