新医学2016，Vol.47Issue(3)：142-145,4.DOI:10.3969/j.issn.0253-9802.2016.03.002
别嘌醇超敏反应研究进展
Research progress of allopurinol-induced hypersensitivity
陈泽娜 1古洁若1
作者信息
- 1. 510630 广州，中山大学附属第三医院风湿免疫科
- 折叠
摘要
Abstract
Allopurinol is one of the most common drugs for decreasing the serum uric acid,and also highly likely to cause severe adverse reactions.Based upon pharmacogenetics and immunological findings, HLA-B*58∶01 was intimately correlated with serious allopurinol-induced adverse reaction,which significantly differed among different populations.In addition,HLA-B*58∶01 gene was neither a sufficient nor necessary factor for allopurinol-related supersensitivity.Currently,HLA-B*58∶01 detection was utilized to predict the incidence of allopurinol-related supersensitivity.However,the application value remains to be further elucida-ted.In this article,pharmacogenetics and immunological studies related to allopurinol-related supersensitivity were summarized.关键词
别嘌醇/超敏反应/HLA-B*58∶01Key words
Allopurinol/Hypersensitivity/HLA-B*58∶01引用本文复制引用
陈泽娜,古洁若..别嘌醇超敏反应研究进展[J].新医学,2016,47(3):142-145,4.
