中国医疗设备2016，Vol.31Issue(2)：18-20,30,4.DOI:10.3969/j.issn.1674-1633.2016.02.004
呼出气监测静脉麻醉药血药浓度
Breath Monitoring of Intravenous Anesthetics Concentration in Blood
摘要
Abstract
Propofol accounts for about 70% market share of intravenous anesthetics in clinical surgery. With further research and application of total intravenous anesthesia, precision closed-loop anesthesia is proved to be important in clinical practice. It is necessary to monitor anesthetic dose, assess anesthesia effect, and evaluate anesthesia prognosis in a rapid and comprehensive way during the closed-loop anesthesia. Due to intravenous injection of anaesthetic, the dififculty to precisely monitor anaesthetic dose in blood has become the main limit for development of precision closed-loop anesthesia. In recent ten years, propofol detection using real-time breath monitoring developed rapidly with novel techniques and methods, which might break through the barrier of the closed-loop anesthesia. This study presents systems and methods using synchronized applications of gas chromatograph (GC) and surface acoustic wave (SAW) sensor for on-line monitoring of propofol in exhaled gas. SPME-GC-MS was used to calibrate to GC-SAW sensor system for verifying feasibility, reliability, detection limit, and linearity. The propofol concentrations in exhaled gas was compared with concentrations in blood calculated by target-controlled infusion (TCI). The results showed a high degree of consistency. In conclusion, GC-SAW system was proved to be a reliable way for clinical monitoring of propofol concentration through patients’exhaled gas. This detection system would reduce the side effects of propofol intravenous anesthesia during surgery.关键词
呼吸检测/气相色谱联用声表面波/丙泊酚/靶控输注Key words
breath detection/gas chromatograph-surface acoustic wave/propofol/target-controlled infusion分类
医药卫生引用本文复制引用
董浩,张冯江,林丽泉,陈璟,王福园,王莹莹,陈星..呼出气监测静脉麻醉药血药浓度[J].中国医疗设备,2016,31(2):18-20,30,4.基金项目
国家自然科学基金项目（No.81201166，No.81571769）。 （）
