医学信息2016，Vol.29Issue(9)：161-162,2.
改良法制作兔VX2骨肿瘤模型的实验研究
Study on the Improved Method in Establishment of VX2 Bone Tumor Model in Rabbit
摘要
Abstract
Objective To investigate the efficacy between the traditional method and the improved method in establishment of VX2 bone tumor model in rabbit in order to prove the improved method can improve tumor cells spreading. Methods After separating the VX2 tumor from cancer bearing VX2 rabbit, the tumor tissue blocks were prepared. the tissue blocks were embedded into the right tibias 22 rabbits through the puncture hole ,and all the puncture holes were closed by bone wax. Color Doppler Ultrasound was used to assess the soft enclosed mass near the puncture hole after 2 weeks. The pathological study also was carried out for the soft tissue near the holes after 14 days. Results Only 2 cases from the left group showed the soft mass around the puncture holes after 14 days, but there were 6 cases around the puncture holes of all the 22 cases of the right group. The pathological showed there were 5 cases (23%,5/22)that we can find the tumor cells in the soft tissue around the puncture hole in the left group, but 12 cases (55%,12/22)in the right group. The difference was statistically significant (χ²=4.69,<0.05). Conclusion The improved method was more convenient in operation and less tumor cells spreading in establishment of bone tumor model compared with the traditional method.关键词
VX2肿瘤/骨肿瘤/模型/病理学Key words
VX2 tumor/Bone tumor/Model/Pathology引用本文复制引用
曹海营,冯震,魏俊强,赵景新,于涛,金宇..改良法制作兔VX2骨肿瘤模型的实验研究[J].医学信息,2016,29(9):161-162,2.基金项目
2014年河北省科技厅指令性项目（课题编号14277790D）；2013河北省重大医学科研课题 （）
