摘要
Abstract
Objective To explore the effective prevention of infection in the process of preparing the fracture model with dose of penicillin. Methods To establish the New Zealand White rabbits femur fracture model and made successful model according to the dose of penicillin different rabbits were randomly divided into three groups, group A after the left gluteus maximus intramuscular penicillin 40 000 u, 1 times / day, for 3 consecutive days, dressing the wound for 7 days, 1 times/ day;group B after operation the left gluteus maximus muscle infusion of penicillin to 40 million U, 1 times/day; patients in group C after left gluteus maximus intramuscular penicillin 80 million U, 1 times / day for 3 consecutive days. 4 weeks after the operation of 3 groups of rabbits after partial layer puncture bacteria culture, blood tests of white blood cells, X-ray examinations were performed after anesthesia. Results The 3 groups after operation early can see the incision oozing, limp, decreased appetite, increased white blood cells. Group A, group B and group C respectively, 2, 11, 2 X-ray showed the classic manifestations of osteomyelitis, for the destruction of the cortex, border is not clear, the dead bone formation, images and bacteria culture can be seen, there is a colony growth. The infection rates of A, B and C were 8%, 44%, 9% (Table 2). Between the three groups, the difference between the two groups was statistically significant between P group and B group, the difference between the two groups was statistically significant; the difference between the B group and the C group was statistically significant; the difference between the A group and the P group was statistically significant between the two groups, the P group and the C group was not statistically significant. Conclusion Penicillin 40 000 u, 1 times / daily intramuscular injection of continuous 3 TICA dressing 7 days or 8 00000 u, 1 times /day, for 3 consecutive days without dressing can effective infection control and can be used in guidance of rabbit fracture or bone nonunion model preparation of anti infection.关键词
股骨/骨折/实验动物模型/青霉素/新西兰大白兔Key words
Femur/Fracture/Experimental animal model/Penicillin/New Zealand White rabbits
