中国感染控制杂志2016，Vol.15Issue(2)：88-92,5.DOI:10.3969/j.issn.1671-9638.2016.02.004
连续4年ICU患者经纤维支气管镜取痰分离病原菌及其耐药性
Distribution and antimicrobial resistance of pathogens from intensive care unit patients’sputum obtained through fiberbronchoscope for four consec-utive years
摘要
Abstract
Objective To investigate the distribution and antimicrobial resistance of pathogens from lower respira-tory tract in patients in intensive care unit (ICU),so as to provide reference for clinical treatment.Methods Distri-bution and antimicrobial susceptibility of pathogens isolated from ICU patients’sputum obtained through fiberbron-choscope between 2011 and 2014 were analyzed retrospectively.Results A total of 3 454 pathogenic strains were isolated between January 1 ,2011 and December 31 ,2014,the percentage of gram-negative bacteria,gram-positive bacteria,and fungi were 84.11 %,14.50%,and 1 .39% respectively.The detection rates of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella spp .in 2011 -2014 were 38.46% -73.33% and 26.95% -37.06% respectively. Enterobacteriaceae strains had low resistance rates to imipenem and meropenem (<20.00%);resistance of Acinetobacter baumannii was higher than Pseudomonas aeruginosa ,both had low resistance rates to amikacin(3.32%-37.16%);vancomycin-and linezolid-resistant strains were not found among Staphylo-coccus .In 2011 - 2014,detection rates of methicillin-resistant Staphylococcus aureus (MRSA)were 42.86% -61 .22%,methicillin-resistant coagulase-negative staphylococcus (MRCNS)were 86.96% - 91 .67%;resistance rates of Enterococcus faecium was higher than Enterococcus faecalis ,vancomycin-resistant strains were not found among Enterococcus faecalis and Enterococcus faecium ;the major fungus was Candida albicans .Conclusion Anti-microbial resistance of pathogens isolated from lower respiratory tract is getting more serious,clinicians should pay attention to non-antimicrobial infection control strategies in addition to rational use of antimicrobial agents.关键词
重症监护病房/下呼吸道/抗药性,微生物/耐药性/病原菌/合理用药Key words
intensive care unit/lower respiratory tract/drug resistance,microbial/drug resistance/pathogen/rational drug use分类
医药卫生引用本文复制引用
朱肖萌,刘瑶,王毅,郗晓婧,于湘友..连续4年ICU患者经纤维支气管镜取痰分离病原菌及其耐药性[J].中国感染控制杂志,2016,15(2):88-92,5.基金项目
国家自然基金 （）
