中国比较医学杂志2016，Vol.26Issue(3)：6-10,5.DOI:10.3969.j.issn.1671-7856.2016.03.002
人工诱导树鼩乳腺肿瘤的病理分析
Pathological analysis of the induced breast tumor models in tree shrew
摘要
Abstract
Objective To establish a tree shrew mode of breast tumor.Method Forty-five 3 to 4 month-old female tree shrews were orally gavaged with 20 mg 7,12-dimethylbenz(a)anthracene (DMBA) or peanut oil per animal for three times.Following that, fifteen DMBA administrated tree shrews were implanted 90 day-release medroxyprogesterone acetate ( MPA) pellets.The tree shrews were palpated once weekly to detect mammary tumors for 45 weeks after first DMBA administration.Results DMBA were able to induce breast tumors (12.5%) in tree shrews, and MPA increased the tumor incidence (50%) while no breast tumors were observed in the control group.Three induced breast tumors were intraductal papillary carcinomas and one was IDC by H&E stain.Conclusion All induced tumors are similar with spontaneous tumors in structure and molecular markers.关键词
树鼩/乳腺肿瘤/模型/动物Key words
Tree shrew/Mammary tumor/Mmodel/animal分类
医药卫生引用本文复制引用
何保丽,夏厚军,角建林,王春艳,张海林..人工诱导树鼩乳腺肿瘤的病理分析[J].中国比较医学杂志,2016,26(3):6-10,5.基金项目
国家自然科学基金项目( 31560613 ) （ 31560613 ）
云南省应用基础研究昆医联合专项 ( 2013FB126 ) （ 2013FB126 ）
云南省应用基础研究计划(2013FZ071). （2013FZ071）
