中国比较医学杂志2016，Vol.26Issue(3)：19-23,5.DOI:10.3969.j.issn.1671-7856.2016.03.005
大肠埃希菌致兔慢性输卵管炎症模型的建立
The establishment of chronic salpingitis model of New Zealand rabbits caused by Escherichia coli
摘要
Abstract
Objective To investigate the possibility of utilizing the mixed bacteria liquid and the Escherichia coli ( E.coli) liquid to establish the chronic salpingitis model of New Zealand rabbits, respectively.Methods Taken as the study object, the un-pregnant New Zealand rabbits (4~5 years old) were randomly divided into three groups: the normal group, the mixed bacteria experimental group and the E.coli experimental group.The trans-vaginal intrauterine intubation operation was performed for the injection of the mixed bacteria liquid and the E.coli liquid.Visual observation was to evaluate the gross pathological changes of the salpingitis and the pelvic cavity.HE staining and the light microscope were used to observe the micro-pathological changes of salpingitis.Results On the 15th day after modeling, increased pelvic effusion, dense peritoneal adhesion, interstitial hyperplasia and infiltration of lymphocytes were observed in both experimental groups. Conclusion Through the trans-vaginal intrauterine intubation operation, the chronic salpingitis model of New Zealand rabbits could be successfully established either by using the mixed bacteria liquid or by using the E.coli liquid.关键词
慢性输卵管炎症模型/混合菌液/大肠埃希菌液/经阴道宫腔内插管灌注术Key words
Chronic salpingitis model/Mixed bacteria liquid/E.coli liquid/Trans-vaginal intrauterine intubation operation分类
生物科学引用本文复制引用
冯子聪,张昭,黎哲,冯博仪,陈思艾,李君宇,肖小敏..大肠埃希菌致兔慢性输卵管炎症模型的建立[J].中国比较医学杂志,2016,26(3):19-23,5.基金项目
国家自然科学基金项目( 81370676 ) （ 81370676 ）
暨南大学国家级大学生创新项目( 201310559069 ) （ 201310559069 ）
广东省科技计划项目(2012B32000007) （2012B32000007）
广州市科技计划项目(7411785665675). （7411785665675）
