中国现代医学杂志2016，Vol.26Issue(6)：19-22,4.DOI:10.3969/j.issn.1005-8982.2016.06.005
Dickkopf1在骨关节炎中作用的初步研究
Role of Dickkopf1 in osteoarthritis
李强 1张志强 1尚雁峰1
作者信息
- 1. 天津市宁河县医院 骨一科，天津 301500
- 折叠
摘要
Abstract
Objective To study the effect and clinical significance of DKK1 on osteoarthritis (OA). Methods In this study, 80 OA cases were selected as OA group, 80 patients without history of OA as normal control group. The serum level of DKK1 was measured by sandwich enzyme linked immunosorbent assay (ELISA) in both groups. The rabbit model of knee osteoarthritis was built. The pathological characteristics of control, model and DKK1 groups were contrasted and the Manikin score was assessed as well. The therapeutic effect of DKK1 was evaluated. Results The serum level of DKK1 in the OA group was significantly lower than that in the control group ( = 0.001). The rabbit model of knee osteoarthritis was built successfully. The Manikin score in the DKK1 group (7.89 ± 0.82) was significantly lower than that in the model group [(12.56 ± 0.51), =0.003], but was significantly higher than that in the control group [(1.08 ± 0.35), =0.001]. Conclusions As the Wnt signaling pathway inhibitor, DKK1 can inhibit osteoblast differentiation, restrain the course of OA; but its mechanism in the human body still needs further re-search.关键词
骨关节炎/DKK1/Wnt信号通路Key words
osteoarthritis/DKK1/Wnt pathway分类
医药卫生引用本文复制引用
李强,张志强,尚雁峰..Dickkopf1在骨关节炎中作用的初步研究[J].中国现代医学杂志,2016,26(6):19-22,4.
