中国现代医学杂志2016，Vol.26Issue(6)：23-26,4.DOI:10.3969/j.issn.1005-8982.2016.06.006
直肠癌白细胞介素-6的表达与临床病理因素的相关性研究
Correlation between IL-6 expression and clinicopathologic features in rectal cancer
摘要
Abstract
Objective To study the correlation between IL-6 and clinicopathologic features in rectal cancer. Methods IL-6 expression was detected by immunohistochemistry and peripheral blood assay in rectal cancer tissues and pericarcinomatous tissues of 49 rectal cancer patients, and 30 healthy people for physical examination were taken as controls. Then its relationship with clinicopathologic features was analyzed. Results IL-6 expression in the rectal cancer tissues was higher than that in the pericarcinomatous tissues. IL-6 expression had no relationship with age, gender, histological type or lymph node metastasis. However, IL-6 protein expression was correlated with clinical stage of rectal cancer. Peripheral blood IL-6 level in the rectal cancer patients was higher than that in the healthy persons before operation. Serum IL-6 level was significantly associated with clinical stage and lymph node metastasis ( < 0.05). Conclusions High-expression of IL-6 is closely associated with the development of rectal cancer. IL-6 may be a key factor of tumor metastasis.关键词
直肠肿瘤/白细胞介素- 6/肿瘤转移Key words
rectal carcinoma/IL-6/tumor metastasis分类
医药卫生引用本文复制引用
刘晓平,周小青,邓伟,钟宝元,曾祥福,吴平辉..直肠癌白细胞介素-6的表达与临床病理因素的相关性研究[J].中国现代医学杂志,2016,26(6):23-26,4.基金项目
江西省教育厅科学技术研究项目 （）
