中国现代医学杂志2016，Vol.26Issue(6)：27-31,5.DOI:10.3969/j.issn.1005-8982.2016.06.007
人类非嗜肝病毒所致肝炎患者临床特征的相关性分析
Correlation analysis of clinical features of patients with hepatitis caused by human non-hepatotropic viruses
古雪 1李铃 1敬雨佳 1李芸 2梅小平1
作者信息
- 1. 川北医学院附属医院 感染科，四川 南充 637000
- 2. 四川大学华西医院，四川 成都 610041
- 折叠
摘要
Abstract
Objective To explore the etiology and clinical features of hepatitis caused by human non-hepatotropic viruses. Methods This clinical research included 176 cases of viral hepatitis caused by non-hepatotropic viruses. Conventional method was used to detect hepatitis A to E markers in 112 cases to exclude hepatotropic virus infec-tion. IgM and IgG antibodies and autoantibodies (mitochondrial antibody and antinuclear antibody) against Herpes simplex virus (HSV), Epstein-Barr virus (EB), Cytomegalovirus (CMV), Coxsackie virus (CoxV) and other viruses were detected. The patients were followed up for 6 months. Their clinical symptoms and signs, and liver function in-dexes were compared with those of the patients with acute viral hepatitis during the same period. Results The most common non-hepatotropic pathogen for viral hepatitis was Cytomegalovirus (34.7%), followed by Epstein-Barr virus and Rotavirus (24.4% and 9.6%). The incidences of fatigue, nausea, anorexia, hepatomegaly and jaundice were sig-nificantly lower while the incidences of splenomegaly and lymph node enlargement were significantly higher in the patients with non-hepatotropic virus hepatitis than in the patients with acute viral hepatitis during the same period ( < 0.01). ALT, AST and TBIL levels in the patients with non-hepatotropic virus hepatitis were significantly lower than those in the patients with acute viral hepatitis ( < 0.01); while albumin and prothrombin time had no statisti-cally significant differences between them ( > 0.05). ALT, AST and TBIL in the patients with single non-hepato-tropic virus infection were significantly lower than those in the patients with compound infection ( < 0.01). Conclusions CMV and EB virus are common pathogens of hepatitis caused by non-hepatotropic viruses. The clinical manifestation is acute liver damage which is lighter than that of acute viral hepatitis and lighter in single infection than in compound infection. The prognosis of non-hepatotropic virus hepatitis is good.关键词
病毒性肝炎/人/非嗜肝病毒/病因学Key words
viral hepatitis/human/non-hepatotropic virus/etiology分类
医药卫生引用本文复制引用
古雪,李铃,敬雨佳,李芸,梅小平..人类非嗜肝病毒所致肝炎患者临床特征的相关性分析[J].中国现代医学杂志,2016,26(6):27-31,5.
