中国现代医学杂志2016，Vol.26Issue(6)：37-44,8.DOI:10.3969/j.issn.1005-8982.2016.06.009
人类白细胞抗原-B等位基因多态性与江苏地区汉族人群2型糖尿病的相关性研究
Association between HLA- B allelic polymorphism and type 2 diabetes mellitus in Han ethnicity of Jiangsu
摘要
Abstract
Objective To explore the association of allele polymorphism with type 2 diabetes mellitus (T2DM) in Han ethnicity of Jiangsu region. Methods One hundred and eighteen patients with clinically diagnosed T2DM were examined. typing was performed using polymerase chain reaction with sequence-based genotyping (PCR-SBT). The frequency of alleles and serotypes in the group with T2DM was compared with that in Han ethnic healthy populations (644 persons and 20248 persons) from Jiangsu branch of Chinese National Marrow Donor Program (CMDP). Results Compared with the hea lthy donors, there was an increased frequency of*1501 (8.90% vs 3.03%, c =0.000, OˆR = 3.13, 95% CI = 1.80-5.42, statistical power = 98.23%) and a decreased frequency of*5801 (1.69% vs 8.62%, c= 0.000, OˆR = 0.18, 95% CI = 0.07-0.50, statistical power = 91.07%) in the group with T2DM. Accordingly, a higher frequency of*15 serotype (21.18% vs 13.03%, c = 0.022, OˆR = 1.79, 95% CI = 1.26-2.55, power = 90.15%) and a lower frequency of HLA-B*58 serotype (1.69%vs. 8.62%, c=0.000, OˆR =0.18, 95%CI=0.07-0.50, power=91.09%) were found in the T2DM group. Conclusions HLA-B*1501 allele may be a marker of susceptibility for T2DM, in reverse, HLA-B*5801 allele is possibly associated with a resistant effect on T2DM in Han ethnicity of Jiangsu region. These data suggest, for the first time, the association of HLA class I genes with the T2DM in Chinese population.关键词
2型糖尿病/HLA-B/等位基因多态性/PCR- SBTKey words
type 2 diabetes/HLA-B/allelic polymorphism/PCR-SBT分类
医药卫生引用本文复制引用
夏玲芝,曹鹏,李晓娥,许涛,Khawar Ali Shahzad,毛源,张厚智,沈传来..人类白细胞抗原-B等位基因多态性与江苏地区汉族人群2型糖尿病的相关性研究[J].中国现代医学杂志,2016,26(6):37-44,8.基金项目
江苏省科技厅科技支撑计划项目资助 （）
