中国现代医学杂志2016，Vol.26Issue(7)：15-19,5.DOI:10.3969/j.issn.1005-8982.2016.07.004
糖尿病视网膜病变患者血清脂氧素A4和血管内皮生长因子的相关性研究
Association of serum lipoxins A4 and VEGF with diabetic retinopathy
张志月 1房辉 2李玉凯 2马一嘉 1王耕银 2张馨心 2邱明月 2张红蕊 1甄艳凤2
作者信息
- 1. 华北理工大学 研究生院，河北 唐山 063009
- 2. 河北省唐山市工人医院 内分泌二科，河北 唐山 063000
- 折叠
摘要
Abstract
Objective To investigate the association of lipoxins A4 (LXA4) and vascular endothelial growth factor (VEGF) with diabetic retinopathy (DR). Methods Ninety diabetic patients were divided into three groups, i.e. no diabetic retinopathy (NDR) group, simple diabetic retinopathy (SDR) group and proliferative di_abetic retinopathy (PDR) group. And 40 normal persons were recruited as the control group. The serum levels of LXA4 and VEGF were examined, and relationship between LXA4 and VEGF was also investigated. Results The serum LXA4 levels in the NDR, SDR and PDR groups were lower than that in the control group ( =0.000). The serum LXA4 levels in the PDR and SDR groups were lower than that in the NDR group ( <0.05). The serum LXA4 level in the PDR group was lower than that in the SDR group ( <0.05). There was no statistical difference in VEGF between the NDR and control groups ( >0.05). The serum VEGF level was higher in the SDR and PDR groups than in the NDR and control groups ( =0.001), and it was also higher in the PDR group than in the SDR group ( <0.05). Serum LXA4 level was negatively correlated with VEGF level ( <0.05). Conclusions Decreased LXA4 and increased VEGF levels in serum may be the risk factors of retinopathy in diabetic patients.关键词
糖尿病视网膜病变/脂氧素A4/血管内皮生长因子Key words
diabetic retinopathy/lipoxins A4/vascular endothelial growth factor分类
医药卫生引用本文复制引用
张志月,房辉,李玉凯,马一嘉,王耕银,张馨心,邱明月,张红蕊,甄艳凤..糖尿病视网膜病变患者血清脂氧素A4和血管内皮生长因子的相关性研究[J].中国现代医学杂志,2016,26(7):15-19,5.
