中国现代医学杂志2016，Vol.26Issue(7)：24-28,5.DOI:10.3969/j.issn.1005-8982.2016.07.006
表皮生长因子受体及其Ⅲ型突变体在人食管癌的表达及意义
Expressions of EGFR and EGFR variant Ⅲ in human esophageal carcinoma and their significance
朱彦红 1韩大正1
作者信息
- 1. 河南大学第一附属医院 消化内科，河南 开封 475001
- 折叠
摘要
Abstract
Objective To detect expression of epidermal growth factor receptor (EGFR) and epidermal growth factor receptor variant Ⅲ (EGFRvⅢ) in human esophageal carcinoma and to explore its relation with the genesis and development of human esophageal cancer and its relationship with clinicopathological parameters. Methods Immunohistochemistry (Maxvision TM2) was used to detect the expressions of EGFR and EGFRv Ⅲprotein in human esophageal cancer tissues of 58 cases and normal esophageal tissue specimens from 20 non-cancer patients. Results Positive expression rates of EGFR and EGFRv Ⅲ in the human esophageal can_cer tissues (65.6% and 58.5% respectively) were higher than those of the normal gastric tissues (30.0% and 0%, <0.01). EGFRv Ⅲ was not expressed in the normal esophageal tissue. Their expressions were irrelated with gender, age, tomor size or tumor location ( >0.05); but were closely related with the degree of differen_tiation, lymph node metastasis, distant metastasis and clinical stages of esophageal cancer patients ( <0.05). Conclusions Over-expression of EGFR and EGFRvⅢ may be closely related to initiation and progression of esophageal cancer. EGFR and EGFRvⅢ could be considered as the markers for predicting the prognosis of human esophageal cancer. And the specific expression of EGFRvⅢ in esophageal carcinoma can make it the ideal target of treatment of esophageal carcinoma.关键词
表皮生长因子受体/表皮生长因子受体Ⅲ型突变体/食管癌/免疫组织化学Key words
EGFR/EGFRvⅢ/esophageal cancer/immunohistochemistry分类
医药卫生引用本文复制引用
朱彦红,韩大正..表皮生长因子受体及其Ⅲ型突变体在人食管癌的表达及意义[J].中国现代医学杂志,2016,26(7):24-28,5.
