中国现代医学杂志2016，Vol.26Issue(7)：29-32,4.DOI:10.3969/j.issn.1005-8982.2016.07.007
胆宁片对胆汁骨桥蛋白的影响
Effect of Danning tablets on osteopontin in bile
郭满 1陈进宏 2张浩 1李伟汉1
作者信息
- 1. 河南省南阳市中心医院，河南 南阳 473000
- 2. 复旦大学附属华山医院，上海 200040
- 折叠
摘要
Abstract
Objective To investigate the mechanism of Danning tablets in the prevention of cholesterol lithogenesis. Methods A rapid method for detection of anti-nucleating factor osteopontin (OPN) was estab_lished. OPN concentrations were detected in serum and bile of the normal group, cholesterol-gallstone group and pigmental-gallstone group. Another group of cholesterol-gallstone patients ( =60) were randomly divided into Danning group, sodium cholate group and control group; and the changes of OPN in serum and bile were observed using ELISA kits. Results The concentrations of OPN in serum and bile in the cholesterol-gallstone patients were significantly higher than those in the pigmental-gallstone and normal groups ( < 0.05). After treatment with Danning tablets for 2 weeks, the serum and bile OPN concentrations significantly increased in the cholesterol-gallstone patients ( < 0.05); but this increase was not found in the other two groups. Conclusions Danning tablets can raise the concentrations of anti-nucleating factor OPN in serum and bile, thereby reduce the risk of cholesterol gallstone formation.关键词
胆宁片/酶联免疫吸附/骨桥蛋白Key words
Danning tablet/enzyme-linked immunosorbent assay/osteopontin分类
医药卫生引用本文复制引用
郭满,陈进宏,张浩,李伟汉..胆宁片对胆汁骨桥蛋白的影响[J].中国现代医学杂志,2016,26(7):29-32,4.
