中国现代医学杂志2016，Vol.26Issue(7)：40-43,4.DOI:10.3969/j.issn.1005-8982.2016.07.009
超声评估乳腺癌新辅助化疗早期疗效的多因素分析
Multivariate analysis of ultrasound evaluation of early response of breast cancer to neoadjuvant chemotherapy
张紫杰 1郭凤娟 1张彦 2白玲 2范雪 2陈翠京2
作者信息
- 1. 河北北方学院，河北 张家口 075000
- 2. 军事医学科学院附属医院 超声科，北京 100071
- 折叠
摘要
Abstract
Objective To analyze and screen the ultrasonic parameters of evaluating the early response of breast cancer to neoadjuvant chemotherapy (NAC), and to build a mathematical model for preliminary evalua_tion. Methods Seventy-nine patients with primary breast carcinoma received unltrosound examination before NAC and after 2 cycles. The parameters of resistance index (RI), peak systole velocity (PSV), strain ratio (SR), the color flow grade and elastic score were obtained. Both single and multiple logistic regression analyses were applied. After the factors with statistical significance were selected, the relevant mathematical model was built and then was evaluated by means of receiver operating characteristic (ROC) analysis. Results The uni_variate analysis showed significant difference in every factor. A mathematical diagnostic model was established based on RI, PSV and SR. And the result of ROC analysis showed it could improve the diagnostic sensitivity and specificity compared with the single-factor mathematical diagnostic model. Conclusions RI, PSV and SR can predict final pathologic response in primary breast cancers after early cycles of NAC. Multivariate regres_sion model has a higher accurate rate of diagnosis than a single factor in predicting the early efficacy of NAC.关键词
超声/乳腺癌/新辅助化疗/Logistic回归Key words
ultrasound/breast carcinoma/neoadjuvant chemotherapy/logistic regression分类
医药卫生引用本文复制引用
张紫杰,郭凤娟,张彦,白玲,范雪,陈翠京..超声评估乳腺癌新辅助化疗早期疗效的多因素分析[J].中国现代医学杂志,2016,26(7):40-43,4.
