中国现代医学杂志2016，Vol.26Issue(7)：78-83,6.DOI:10.3969/j.issn.1005-8982.2016.07.018
阿立哌唑与奥氮平对精神分裂症患者血糖、血脂影响的Meta分析
Effect of Aripiprazole and Olanzapine on blood glucose and lipids of patients with schizophrenia：meta-analysis
摘要
Abstract
Objective To evaluate the side effects of Aripiprazole and Olanzapine on blood glucose and blood lipids of patients with schizophrenia using meta-analysis. Methods The databases such as CBM, VIP, CNKI, WanFang, PubMed, Elsevier and Cochrane Library, etc. were searched to collect randomized controlled trials (RCTs) from January 1, 2011 to July 31, 2015, and the relevant Internet literature and books were also searched by hand. The literature quality was independently evaluated and cross-checked by three reviewers according to the Cochrane collaboration bias scale, and meta-analysis was applied to the results of homoge_neous studies with RevMan 5.2 software. Results A total of 9 randomized controlled studies (915 patients) were included. The meta-analysis results showed that the levels of fasting blood glucose, triglycerides and choles_terol of the patients with schizophrenia significantly increased after taking regular doses of Olanzapine com_pared to those taking Aripiprazole ( <0.05). Conclusions Aripiprazole is more secure than Olanzapine in as_pects of blood glucose, blood lipids and other side-reactions in patients with schizophrenia.关键词
阿立哌唑/奥氮平/随机对照试验/精神分裂症/Meta分析Key words
Aripiprazole/Olanzapine/randomized controlled trial/schizophrenia/meta-analysis分类
医药卫生引用本文复制引用
邹卿,孙伟铭,袁也丰,童恋茹,姜超..阿立哌唑与奥氮平对精神分裂症患者血糖、血脂影响的Meta分析[J].中国现代医学杂志,2016,26(7):78-83,6.基金项目
江西省研究生创新项目 （）
