中国药房2016，Vol.27Issue(8)：1048-1050,3.DOI:10.6039/j.issn.1001-0408.2016.08.12
曲马多、芬太尼、昂丹司琼与0.9％氯化钠注射液在镇痛泵中的配伍稳定性考察
Stability Study of Tramadol,Fentanyl and Ondansetron Combined with 0.9% Sodium Chloride Injection in Analgesia Pump
摘要
Abstract
OBJECTIVE:To study the stability of Tramadol hydrochloride,Fentanyl citrate and Ondansetron hydrochloride in-jection in 0.9% Sodium chloride injection. METHODS:At room temperature [(25±1)℃],three injections were poured into infu-sion bag of disposable analgesia pump,and diluted with 0.9% Sodium chloride injection. The changes in precipitation,turbidity, color and pH value of the mixture were observed. The relative percentage of three injections within 72 h were determined by HPLC method. RESULTS:There was no significant change in the pH value and appearance of the mixture. Relative percentage of tramad-ol hydrochloride,fentanyl citrate and ondansetron hydrochloride were all higher than 97% within 72 h. CONCLUSIONS:The mix-ture of Tramadol hydrochloride,Fentanyl citrate and Ondansetron hydrochloride injection in 0.9% Sodium chloride injection keep stable within 72 h under room temperature.关键词
曲马多/芬太尼/昂丹司琼/配伍/稳定性/高效液相色谱法Key words
Tramadol/Fentanyl/Ondansetron/Compatibility/Stability/HPLC分类
医药卫生引用本文复制引用
陈雯,方宝霞,刘慧敏,陈富超,朱军..曲马多、芬太尼、昂丹司琼与0.9％氯化钠注射液在镇痛泵中的配伍稳定性考察[J].中国药房,2016,27(8):1048-1050,3.基金项目
湖北省卫生计生委科研基金项目（No.WJ2015MB 290) （）
