中国药房2016，Vol.27Issue(8)：1055-1057,3.DOI:10.6039/j.issn.1001-0408.2016.08.14
不同处方全肠外营养液的稳定性考察
Stability Investigation of Total Parenteral Nutrition Solution of Different Prescriptions
高声传 1李杨1
作者信息
- 1. 沈阳军区总医院药剂科，沈阳 110016
- 折叠
摘要
Abstract
OBJECTIVE:To investigate the number of insoluble particle in total parenteral nutrition(TPN)solutions and to pro-vide reference for clinical application. METHODS:6 kinds of commonly used TPN prescriptions were selected. After prepared ac-cording to sterile operation procedure,TPN at 25℃was investigated at 0,1,4,8 and 24 h in terms of appearance,pH value,os-motic pressure and the numbers of insoluble particles. RESULTS:The appearance and pH value of TPN had no significant change within 24 h after preparation,and osmotic pressures were all lower than 900 mOsm/L. Study results showed that the numbers of in-soluble particles quickly increased,and ≥10 µm and ≥25 µm insoluble particles exceeded the limitation of Chinese Pharmacopoe-ia after Lipid-soluble vitamin for injection were injected into TPN. Medium/long chain fat emulsion injection,water-soluble vita-min,electrolytes and trace elements also increased the numbers of insoluble particles. CONCLUSIONS:Medium/long chain fat emulsion injection,lipid-soluble/water-soluble vitamin,vitamin C,electrolytes and trace elements have certain influence on the number of insoluble particle of TPN. To analyze the reason for the forming of insoluble particles has great meaning both for improv-ing the TPN quality and reducing the harm of particles for patients.关键词
全肠外营养液/不溶性微粒/配伍/稳定性Key words
Total parenteral nutrition/Insoluble particle/Compatibility/Stability分类
医药卫生引用本文复制引用
高声传,李杨..不同处方全肠外营养液的稳定性考察[J].中国药房,2016,27(8):1055-1057,3.
