中国药房2016，Vol.27Issue(8)：1061-1063,3.DOI:10.6039/j.issn.1001-0408.2016.08.16
舟山地区耐亚胺培南铜绿假单胞菌耐药特征及感染危险因素分析
Analysis of Drug Resistance Characteristics of Imipenem-resistant Pseudomonas aeruginosa and Infection Risk Factors in Zhoushan Area
孙春雷 1干朝晖 1姚宝锋1
作者信息
- 1. 舟山市普陀区人民医院重症医学科，浙江舟山 316100
- 折叠
摘要
Abstract
OBJECTIVE:To provide reference for imipenem-resistant Pseudomonas aeruginosa infection control. METHODS:114 patients infected with imipenem-resistant P. aeruginosa were selected from 3 tertiary hospitals in Zhoushan during Feb. 2013 to Feb. 2014. 114 strains of P. aeruginosa were isolated from clinical specimens,and drug resistance characteristics and carbapene-mase-producing gene diversity were analyzed. 101 inpatients with imipenem-resistant P. aeruginosa infection were included in con-trol group;univariate and multivariate Logistic regression analysis were adopted to explore the risk factors of imipenem-resistant P. aeruginosa infection. RESULTS:114 strains were sensitive to polymyxin B,and had different levels of resistance to other 9 kinds of antibiotics. Carbapenemase-producing gene were mainly IMP and VIM type gene. Long-term hospitalization,mechanical ventila-tion,used imipenem and early combined use of antibiotics were risk factors of imipenem-resistant P. aeruginosa infection. CON-CLUSIONS:In Zhoushan area,imipenem-resistant P. aeruginosa shows serious drug resistance. To avoid long-term hospitalization and early combined use of antibiotics can reduce imipenem-resistant P. aeruginosa infection.关键词
亚胺培南/铜绿假单胞菌/耐药性/碳青霉烯酶/基因多态性/危险因素Key words
Imipenem/Pseudomonas aeruginosa/Drug resistance/Carbapenemases/Gene diversity/Risk factor分类
医药卫生引用本文复制引用
孙春雷,干朝晖,姚宝锋..舟山地区耐亚胺培南铜绿假单胞菌耐药特征及感染危险因素分析[J].中国药房,2016,27(8):1061-1063,3.
