中国药房2016，Vol.27Issue(8)：1074-1077,4.DOI:10.6039/j.issn.1001-0408.2016.08.20
托伐普坦联合左西孟旦治疗顽固性心力衰竭的疗效观察
Efficacy Observation of Tolvaptan Combined with Levosimendan in the Treatment of Severe Decompensat-ed Heart Failure
摘要
Abstract
OBJECTIVE:To evaluate therapeutic efficacy of tolvaptan combined with levosimendan in the treatment of severe congestive heart failure(CHF). METHODS:100 severe CHF patients were randomly divided into basic treatment group,tolvaptan group,levosimendan group and drug combination group,with 25 cases in each group. All groups were given Digitalis,ACEI,spi-rolactone,furosemidum and other comprehensive treatment;tolvaptan group was additionally given tolvaptan(15 mg/time,qd);le-vosimendan group given levosimendan [0.1 µg/(kg·min)] for consecutive 24 h;drug combination given tolvaptan (15 mg/time, qd)and levosimendan [0.1 µg/(kg·min)] for consecutive 24 h. Blood pressure,heart rate,dyspnea,the improvement of systemic clinical symptoms and 24 h urine volume were observed in 4 groups before and 7 d after treatment. The venous blood samples were collected to determine the change of Na+,K+,renal function,BNP and other related indicators;the changes of LVEDd,LVESd, LVEF,CI and other indicators were determined by UCG. RESULTS:7 days after administration,compared with basic treatment group,the blood pressure,heart rate,BNP,LVEDd and LVESd of tolvaptan group,levosimendan group and drug combination group decreased significantly,while dyspnea,systemic clinical symptoms and LVEF were improved significantly,and 24 h urine volume and CI increased significantly,with statistical significance(P<0.05). The change of drug combination group was more sig-nificant,there was statistical significance,compared with tolvaptan group and levosimendan group(P<0.05). There was no signifi-cant difference in serum electrolytes and renal function. CONCLUSIONS:Tolvaptan combined with levosimendan is effective and better than drug alone in the treatment of severe CHF.关键词
托伐普坦/左西孟旦/联合用药/顽固性心力衰竭/疗效Key words
Tolvaptan/Levosimendan/Drug combination/Severe decompensated heart failure/Efficacy分类
医药卫生引用本文复制引用
王晓琳,周元丽,孙伟,李莉..托伐普坦联合左西孟旦治疗顽固性心力衰竭的疗效观察[J].中国药房,2016,27(8):1074-1077,4.基金项目
国家自然科学基金（青年基金）资助项目（No.81200211）；山东省重点研发计划立项（No.2015GGA01027）；山东省优秀中青年科学家科研奖励基金立项（No.2012BSA01018）；济南青年科技明星计划项目 （）
