中国药理学通报2016，Vol.32Issue(4)：445-450,6.DOI:10.3969/j.issn.1001-1978.2016.04.001
慢性间歇性低氧动物模型的比较
Research progress of chronic intermittent hypoxia animal models
摘要
Abstract
Chronic intermittent hypoxia ( CIH ) caused by ob-structive sleep apnea hypopnea syndrome( OSAHS) is an impor-tant factor causing or aggravating many kinds of cardiovascular and cerebrovascular diseases. Establishing a rational animal model for intermittent hypoxia is an essential method to study the CIH related cardiovascular diseases. Recently, researchers have tended to simulate intermittent hypoxia condition by controlling the oxygen concentration of the environmental air around the ani-mals. In the paper, we summarize and compare the methods of making intermittent hypoxia animal model in recent literature, from aspects of experimental animals, gas control apparatus, gas species and concentration, intermittent hypoxia treatment time, and anoxic cycle mode.关键词
动物模型/间歇性低氧/阻塞性睡眠呼吸暂停低通气综合征/心血管疾病/高血压/动脉粥样硬化Key words
animal models/chronic intermittent hypoxia (CIH)/obstructive sleep apnea hypopnea syndrome(OSAHS)/cardiovascular diseases/hypertension/atherosclerosis( AS)分类
医药卫生引用本文复制引用
马林沁,张京春,刘玥..慢性间歇性低氧动物模型的比较[J].中国药理学通报,2016,32(4):445-450,6.基金项目
国家自然科学基金资助项目( No 81373825,81573817,81403266) （ No 81373825,81573817,81403266）
国家中医临床基地行业专项课题( No JDZX2012108) （ No JDZX2012108）
