中国药理学通报2016，Vol.32Issue(4)：463-467,5.DOI:10.3969/j.issn.1001-1978.2016.04.005
Notch信号通路在糖尿病并发症中的研究进展
Research progress on Notch signaling pathway and diabetic complications
摘要
Abstract
Notch signaling, a highly conserved pathway, is wide-ly found in invertebrates and vertebrates. By mediating cell com-munication, it can regulate many physiological and pathological processes in various kinds of cells, including cell proliferation, differentiation and apoptosis in multi-cellular organism. Accu-mulating evidence shows that abnormality in Notch signaling is highly related to diabetes mellitus and its complications. Accord-ingly, this paper reviews the molecular basis of Notch signaling and the relations between its abnormal expression and diabetes mellitus, and focuses on the impact of key elements in the Notch signaling pathway on diabetic complications as well as correlative mechanisms.关键词
糖尿病/Notch/信号通路/视网膜/心肌病/并发症Key words
diabetes mellitus/Notch/signaling pathway/reti-na/cardiomyopathy/complication分类
医药卫生引用本文复制引用
张彬,孟祥宝,陈亚萍,孙桂波,孙晓波..Notch信号通路在糖尿病并发症中的研究进展[J].中国药理学通报,2016,32(4):463-467,5.基金项目
国家科技部“重大新药创制”科技重大专项资助项目( No 2012ZX09501001-004) （ No 2012ZX09501001-004）
北京市科技计划课题( No Z141100002114044) （ No Z141100002114044）
