中国药理学通报2016，Vol.32Issue(4)：525-529,530,6.DOI:10.3969/j.issn.1001-1978.2016.04.017
瑞舒伐他汀减轻ApoE-/-小鼠动脉硬化形成与ST6 Gal-Ⅰ表达相关性研究
Correlation of ST6 Gal-Ⅰ expression and atherosclerotic plaque reduction induced by rosuvastatin in ApoE-/- mice
摘要
Abstract
Aim To investigate whether rosuvastatin induced reduction of atherosclerotic plaque was related to the expression of Sialyltransferase ( ST6 Gal-Ⅰ) in ApoE-/ - mice. Methods Six-weeks old ApoE-/ -mice fed with high fat were divided randomly into three groups: baseline group ( n=12 ) , control group ( n=12 ) and rosuvastatin group ( n =12 ) . Sixteen weeks later, control group was sacrificed. Serum and aortic intima were saved. Control group and rosuvastatin group were fed for seven weeks continually. Concentra-tions of serum lipids(TC, TG, LDL and HDL) were analyzed. Sections from the aortic root were examined by Hematoxylin-Eosin( HE) staining. The size of ath-erosclerotic lesion in each section was evaluated. Ex-pression of ST6 Gal-Ⅰ in aortic intima was detected by immunohistochemistry. Results Plasma TG and LDL-C, plaque areas and intimal thickness of control group were significant higher than those of baseline group ( P<0. 05 ) . Those results indicated that the AS model was successfully constructed. After seven weeks, the plaque areas and concentrations of serum lipids of rosu-vastatin group were obviously smaller than those of con-trol group(P<0. 05). The expression of ST6Gal-Ⅰin aortic root was decreased in control group compared to the baseline, and which was increased in control group compared to the rosuvastatin group. Conclusion Ro-suvastatin could inhibit the progression of atherosclero-sis, which might be related to the expression of ST6Gal-Ⅰ in aortic root.关键词
动脉粥样硬化/高胆固醇血症/ApoE-/ -小鼠/斑块/瑞舒伐他汀/唾液酸转移酶Key words
atherosclerosis/hypercholestrolemia/ApoE-/ - mice/plaque/rosuvastatin/ST6 Gal-Ⅰ分类
医药卫生引用本文复制引用
刘燕,张军,蒲强红,邓潇,于超..瑞舒伐他汀减轻ApoE-/-小鼠动脉硬化形成与ST6 Gal-Ⅰ表达相关性研究[J].中国药理学通报,2016,32(4):525-529,530,6.基金项目
国家自然科学基金资助项目( No NSFC 81370403) （ No NSFC 81370403）
高等学校博士学科点专项科研基金资助课题( No 20125503110008) （ No 20125503110008）
