中国药业2016，Vol.25Issue(1)：22-24,3.
酮洛芬固体分散体的制备及其体外溶出度研究
Preparation and In-Vitro Dissolution of Ketoprofen Solid Dispersion
王小宁 1张存劳 1马婷1
作者信息
- 1. 西安医学院药学院，陕西 西安 710021
- 折叠
摘要
Abstract
Objective To prepare ketoprofen solid dispersion and to investigate its in-vitro dissolution. Methods Polyethylene glycol was selected as matrix to prepare solid dispersion by melting method. Orthogonal design was used to optimize the prescription and pro-cess. Powder X-ray was used to characterize the solid dispersion and the in-vitro dissolution was investigated. Results The optimal preparation and process of ketoprofen solid dispersion was prepared at temperature of 100 ℃ for 30 min with PEG 6000 as a carrier and the drug and carrier ratio was 1:5. The in-vitro dissolution rate was 94. 5% during 45 min in the medium of pH= 7. 6. Conclusion Solid dispersion can significantly improve the in-vitro dissolution rate of ketoprofen.关键词
酮洛芬/固体分散体/体外溶出度/聚乙二醇Key words
ketoprofen/solid dispersion/in-vitro dissolution/polyethylene glycol分类
医药卫生引用本文复制引用
王小宁,张存劳,马婷..酮洛芬固体分散体的制备及其体外溶出度研究[J].中国药业,2016,25(1):22-24,3.
