中国药业2016，Vol.25Issue(1)：39-40,41,3.
左西孟旦治疗冠脉搭桥术后低心排综合征并急性肾损伤20例临床评价
Levosimendan for Treating Low Cardiac Output Syndrome with Acute Kidney Injury after Coronary Artery Bypass Grafting in 20 Cases
施乾坤 1章淬 1肖继来1
作者信息
- 1. 南京医科大学附属南京医院·南京市第一医院重症医学科，江苏 南京 210006
- 折叠
摘要
Abstract
Objective To observe the clinical efficacy of levosimendan in treating low cardiac output syndrome with acute kidney injury after coronary artery bypass grafting. Methods 40 cases of coronary artery bypass grafting patients with postoperative low cardiac output syndrome complicated with acute renal injury were randomly divided into control group and observation group, 20 cases in each group. The control group was treated with dopamine treatment, and the observation group was treated with levosimendan injection treat-ment. The left ventricular ejection fraction ( LVEF ) , left ventricular fractional shortening ( LVFS ) in evaluation of cardiac output of the two groups were observed before and after the operation; at the same time, the serum creatinine ( Cr ) , Cystatin C ( Cys C ) level, calculated glomerular filtration rate ( GFR ) were observed to evaluate the renal function damage degree. In addition, the adverse drug reactions were observed in two groups during the process of treatment. Results After treatment, the LVEF and LVFS levels of the two groups were significantly improved than before treatment ( P < 0. 05 ) , and the improvement of the observation group was more significantly than that of the control group ( P < 0. 05 );the levels of Cr and Csy C were significantly increased ( P < 0. 05 ) , and the Csy C of the observation group increased more significantly than that in control group ( P < 0. 05 );the GFR levels of the two groups were significantly decreased ( P < 0. 05 ) , and the observation group decreased more obviously than the control group ( P < 0. 05 ) . The incidence of adverse events in the control group was significantly higher than the observation group ( P < 0. 05 ) . Conclusion The levosimendan treatment is safe and exact, can significantly improve the cardiac output after coronary artery bypass grafting, and can significantly reduce the low cardiac output syndrome of acute injury of renal function.关键词
左西孟旦/冠状动脉搭桥术/低心排综合征/急性肾损伤/安全性Key words
levosimendan/coronary artery bypass grafting/low cardiac output syndrome/acute kidney injury/safety分类
医药卫生引用本文复制引用
施乾坤,章淬,肖继来..左西孟旦治疗冠脉搭桥术后低心排综合征并急性肾损伤20例临床评价[J].中国药业,2016,25(1):39-40,41,3.
