中国药业2016，Vol.25Issue(2)：68-69,2.
高效液相色谱法测定胃乐胶囊中硫酸阿托品含量
Determination of Atropine Sulfate in Weile Capsules by HPLC
李德潮1
作者信息
- 1. 广西医科大学制药厂，广西 南宁 530021
- 折叠
摘要
Abstract
Objective To establish an HPLC method for the determination of atropine sulfate in Weile Capsules. Methods The chro-matographic column was the Kromasil C18 column(250 mm × 4. 6 mm,5 μm)at the temperature of 30 ℃,with 0. 05 mol/L sodium di-hydrogen phosphate solution(adjusting pH to 2. 8 with phosphoric acid)-acetonitrile(90 :10) as the mobile phase and detected with UV 210 nm and the flow rate of 1. 0 mL/min. Results The Atropine Sulfate in the range of 10. 0-100. 0 μg/mL showed good lin-ear relatiomship with the peak area,the average recovery rate was 98. 88%,RSD=0. 50% ( n=6 ) . Conclusion This method is accurate,sensitice and reproducible,which can be used for the determination of atropine sulfate in Weile Capsules.关键词
高效液相色谱法/胃乐胶囊/硫酸阿托品/含量测定Key words
HPLC/Weile Capsules/atropine sulfate/content determination分类
医药卫生引用本文复制引用
李德潮..高效液相色谱法测定胃乐胶囊中硫酸阿托品含量[J].中国药业,2016,25(2):68-69,2.
