摘要
Abstract
OBJECTIVE:To investigate the clinical efficacy of clopidogrel combined with aspirin in treatment of stable coronary heart disease .METHODS:180 cases with stable coronary artery disease admitted into hospital from Jan .2014 to Jan.2015 were selected to be divided into two groups via the random number table , with 90 cases in each.All patients were given routinely lipid regulation , blood pressure , blood glucose control and anti-ischemic drug therapy .Based on the routine therapy, the observation group received clopidogrel , while the control group received aspirin .After follow-up of 30 d, the changes of platelet aggregation rate (PAR), attack time of angina, improvement of ST in ECG and occurrence of adverse reactions were compared between two group of patients .RESULTS: The PAR in observation group decreased from (63.7 ±10.2)% before treatment to (42.3 ±9.1)% after treatment, as for the control group, it decreased from (62.8 ±9.4)%to (49.4 ±10.2)%, the data were significantly lower than before treatment for the same group , and the decline in observation group was significantly greater than than of control group , with statistically significance (P<0.05). There were 3 cases (3.7%) with the deterioration of diseases in observation group , 10 cases(10.1%) in control group, the difference was statistically significant between two groups ( P<0.05 ) .The total effective rate of observation group were 96.7%, significantly higher than that of control group 71.1%, with statistical significance (P<0.05).The average attack time of angina in observation group were (1.3 ±1.1) d, significantly lower than that in control group (2.4 ±1.2) d, the difference was statistically significant ( P<0.05) .Meanwhile , the total effective rate of improvement of ST in ECG in observation group were 86.7%, higher than that in control group 70.0%, the difference was statistically significant ( P<0.05).And one case (1.1%) with intestinal discomfort in observation group , 4 cases (4.5%) with gingival bleeding and 4 cases of ( 4.5%) with digestive tracthemorrhage in control group , with statistically significant difference ( P<0.05).CONCLUSIONS:The clinical efficacy of clopidogrel and aspirin in treatment of stable coronary heart disease is relatively good , but clopidogrel has a safer clinical effect , which is worthy of worthy of clinical popularization and application .关键词
氯吡格雷/阿司匹林/稳定型冠心病/心绞痛Key words
Clopidogrel/Aspirin/Stable coronary artery disease/Angina分类
医药卫生
