摘要
Abstract
OBJECTIVE:To probe into the effects and adverse reactions of clozapine combined with paliperidone in treatment of refractory schizophrenia .METHODS:120 cases of refractory schizophrenia admitted into Guangzhou Hospitals of Traditional Chinese and Western Medicine from Nov .2013 to jan.2015 were selected to be divided into observation group and control group, with 60 cases in each.The control group were treated with clozapine , while the observation group received clozapine combined with paliperidone;the efficacy and adverse reactions in two groups were evaluated by positive and negative symptom assessment scale score .RESULTS: The total efficacy of observation group was 85.00%(51/60), significantly higher than that of control group 50.00%(30/60), with statistically significant difference (P <0.05).In observation group , the quality of life score , the improvement score of psychiatric symptoms and the control time of schizophrenia were respectively (3.11 ±10.90) scores, (38.11 ±10.97) scores and (11.87 ±2.38) d, while in control group were respectively (2.71 ±0.67) scores,(32.76 ±12.37) scores and (17.29 ±3.21) d;with statistically significance (P<0.05).There were 4 cases with gain of body mass in observation group , and control group were 12 cases, the difference was significant (P<0.05).There was no significant difference in the incidence of adverse reactions between two group of patients (P>0.05).CONCLUSIONS:Clozapine combined with paliperidone can improve the clinical symptoms of refractory schizophrenia , with few adverse reactions .It is worthy of clinical promotion .关键词
难治性精神分裂症/氯氮平/帕利哌酮/阳性和阴性症状量表评分/不良反应Key words
Refractory schizophrenia/Clozapine/Paliperidone/Positive and negative syndrome scale score/Adverse reactions分类
医药卫生
