中国医院用药评价与分析2016，Vol.16Issue(2)：201-205,5.DOI:10.14009/j.issn.1672-2124.2016.02.022
特比萘芬和伊曲康唑治疗甲真菌病疗效和安全性的 Meta分析
Meta-analysis on Efficacy and Safety of Terbinafine and Itraconazole in Treatment of Onychomycosis
马丽萍 1沈司京 1吝战权 1陈灿 1张蕾1
作者信息
- 1. 北京大学首钢医院药剂科，北京 100144
- 折叠
摘要
Abstract
OBJECTIVE:To systematically assess the efficacy and safety of terbinafine and itraconazole in treatment of onychomycosis , and to provide reference for the selection of antibiotics in the treatment of onychomycosis . METHODS:Computers was used to retrieve the Cochrane Central Register of Controlled Trials , EMbase , PubMed and Chinese Bio-Medicine Database and Wanfang database and some related literatures manually searched until Nov . 2014 .Randomized controlled trails ( RCT ) with comparison of efficacy and safety of terbinafine and itraconazole in treatment of onychomycosis in English and Chinese were searched , the data were extracted and the methodological quality of the included studies were assessed .The Cochrane Collaboration ’ s software RevMan 5 .1 was used for meta-analysis.RESULTS:There were 10 RCT, including 1 839 cases in meta-analysis, of which effectiveness(fungus cure rate) of 10 trials(1 839 patients) were assessed;and the fungus cure rate of terbinafine group was significantly higher than that of itraconazole group, with statistically significant difference [RR =1.29, 95%CI =(1.13,1.46), P <0.000 1].9 trials (1 711 patients) had adverse drug reactions, there were no significant difference between two groups[RR =1.04,95%CI =(0.84,1.29),P =0.72].The incidence of stomachache in terbinafine group was significantly higher than that in itraconazole group ( P=0.05 ) , but the incidence of liver function abnormalities in terbinafine group was significantly lower than that in itraconazole group ( P≤0.05 ) .No severe adverse reactions were observed in all trials .CONCLUSIONS:Current clinical evidence shows that terbinafine and itraconazole in treatment of onychomycosis have higher fungus cure rate and safety .And terbinafine is more effective than itraconazole in treatment of onychomycosis without severe adverse reactions .关键词
特比萘芬/伊曲康唑/甲真菌病/Meta分析Key words
Terbinafine/Itraconazole/Onychomycosis/Meta-analysis分类
医药卫生引用本文复制引用
马丽萍,沈司京,吝战权,陈灿,张蕾..特比萘芬和伊曲康唑治疗甲真菌病疗效和安全性的 Meta分析[J].中国医院用药评价与分析,2016,16(2):201-205,5.
