中国中西医结合外科杂志2016，Vol.22Issue(2)：112-116,5.DOI:10.3969/j.issn.1007-6948.2016.02.002
树突状细胞疫苗联合细胞因子诱导的杀伤细胞治疗用于预防结直肠癌术后复发转移的临床疗效观察
Clinical Effects of Immunotherapy with Dendritic Cell Vaccine and Ctokine-induced Killer Cells in Pre? vention of Recurrence and Metastasis for post-Surgery Colorectal Cancer Patients
摘要
Abstract
Objective To evaluate the clinical effects of immunotherapy with dendritic cells (DC) and cyto?kine-induced Killer (CIK) cells on prevention of recurrence and metastasis in post-surgery patients with colorec?tal cancer (CRC). Methods A total of 74 post-surgery patients with CRC were randomly divided into two groups. 24 cases who received immunotherapy with DC and CIK were defined as group I, 50 cases who did not received the immunotherapy were defined as group NI. Delayed type hypersensitivity (DTH) skin test results and fever were abserved in Group I. Quality of life (QOL) and disease-free survival (DFS) were analyzed in both groups. Results Positive rates of DTH and fever were 12/24(50.00%)and 8/24(33.33%)respectively in group I. Quality of life (QOL) by Karnofsky in group I was 8/24(33.33%)which was higher than that in group NI(19/50,18.00%, χ2=7.063 P=0.029). DFS in group I (298 days) was longer than DFS in group NI (200 days, χ2=4.304 P=0.038). Conclusion Immunotherapy with DC and CIK maybe improve QOL and prolong DFS in post-surgery CRC.关键词
结直肠癌/无病生存期/树突状细胞/细胞因子诱导杀伤细胞Key words
Colorectal cancer/disease-free sur?vival/dendritic cells/cytokine-induced killer cells分类
医药卫生引用本文复制引用
牛静秀,张利红,李佳丽,朱慧,庞雁,李维廉..树突状细胞疫苗联合细胞因子诱导的杀伤细胞治疗用于预防结直肠癌术后复发转移的临床疗效观察[J].中国中西医结合外科杂志,2016,22(2):112-116,5.基金项目
天津市科技计划项目(12ZCDZSY17100) （12ZCDZSY17100）
