中国中西医结合外科杂志2016，Vol.22Issue(2)：116-119,4.DOI:10.3969/j.issn.1007-6948.2016.02.003
自体免疫细胞治疗联合化疗治疗大肠癌的临床研究
Clinical Study of Autoimmune Cells Therapy combined with Chemotherapy for Colorectal Cancer
摘要
Abstract
Objective: To investigate clinical application value of dendritic cells combined with cyto?kine-induced killer (DC-CIK) in the treatment of colorectal cancer. Methods Two hundred and forty-two cas?es of postoperative patients of colorectal cancer treated with chemotherapy combined with DC-CIK in Tianjin People's Hospital were selected as combined treatment group, and 463 cases of colorectal cancer treated with chemotherapy were selected as control group. The type hypersensitivity delayed (DTH) skin test was performed at the end of cell therapy. The changes of physical activity, appetite and sleep were recorded. Results In 57.85% of the patients in combined treatment group, DTH was activated. In the same group,there are 185 cases (76.45%) with at least 2 indexes of quality of life being improved. The combined treatment group and control group were compared in 18 months of survival. The survival rate of combined treatment group was 95.04%, and that of the control group was 89.63%. The difference was significant (P=0.016). Conclusion Combined DC-CIK cell therapy and chemotherapy can activate the immune function of patients, improve the quality of life, and improve the survival rate.关键词
早期结直肠癌/树突状细胞疫苗/细胞因子诱导的杀伤细胞/疗效评价Key words
Postoperative patients of colorectal/cancer/dendritic cells/cytokine-induced killer/clinical effects分类
医药卫生引用本文复制引用
朱卫,李佳丽,张利红,牛静秀,尹晓东,杨雪晶,李敬,庞雁..自体免疫细胞治疗联合化疗治疗大肠癌的临床研究[J].中国中西医结合外科杂志,2016,22(2):116-119,4.基金项目
浦东新区科技发展基金(PKF2015-C12) （PKF2015-C12）
