中国中西医结合外科杂志2016，Vol.22Issue(2)：135-138,4.DOI:10.3969/j.issn.1007-6948.2016.02.008
氨甲环酸不同途径用药对全膝关节置换术失血量的影响
Comparison of Effects on Intravenous and Intra-Articular Cavity Injection of Tranexamic Acid on Blood Loss Volume in Total Knee Arthroplasty
石永进 1王全彬 1邱庆虎1
作者信息
- 1. 河北省清河县人民医院骨科 清河 054800
- 折叠
摘要
Abstract
Objective To compare the effects and operative safety of intravenous drip and intra-articular cavity local injection of tranexamic acid on controlling blood loss volume in total knee arthroplasty. Methods Totally 73 patients with total knee arthroplasty treated in the hospital from January 2012 to October 2014 were randomly divided into the intravenous drip group(IVTA)(40 cases) and the intra-articular use group(IATA) (33 cases). The patients in the control group used intravenous tranexamic acid 10 mg/kg,with the maximum dose 1.0g during the anesthetic induction period,while the patients in the treatment group were intra-articularlly injected by tranexamic acid 1g at the finishing of articular capsule suture and before relaxing the tourniquet.The postoperative blood loss,the hidden blood loss,prothrombin time (PT),activated partial thromboplastin time (APTT) were recorded for both groups. Deep-vein thrombosis (DVT) were observed. Results The postopera?tive blood loss and the hidden blood loss of IATA group [(252±63)mL,(603±59)mL]was lower than that of IV?TA group [(545±61.87)mL,(882±114)mL](P＜0.05).There were no significant differences in the two groups in PT、APTT、INR[(13±1.1)vs(12±0.8),(32±2.1)vs(33±1.8),(1±0.1)vs(1±0.1)](P＞0.05). Conclusion Tranexam?ic acid injected intra-articular can significantly and safely reduce blood loss with no increasing risk of deep ve?nous thrombosis.关键词
氨甲环酸/全膝关节置换术/局部注射/静脉滴注Key words
Total knee arthroplasty/tranexamic acid/intra-articular injection/intravenous drip分类
医药卫生引用本文复制引用
石永进,王全彬,邱庆虎..氨甲环酸不同途径用药对全膝关节置换术失血量的影响[J].中国中西医结合外科杂志,2016,22(2):135-138,4.
