中国中西医结合外科杂志2016，Vol.22Issue(2)：146-149,4.DOI:10.3969/j.issn.1007-6948.2016.02.011
右美托咪啶在急腹症手术中的应用
Application of Dexmedetomidine in Operations for Acute Abdominal Diseases
章静 1宋凯 2徐家济 1余剑波3
作者信息
- 1. 北京市丰台右安门医院麻醉科 北京 100071
- 2. 天津市黄河道医院麻醉科 天津 300110
- 3. 天津市南开医院麻醉科 天津 300100
- 折叠
摘要
Abstract
Objective To investigate the clinical advantages of dexmedetomidine in acute abdominal oper?ations. Methods Ninety-one cases of acute abdominal diseases were operated with different anesthetic drugs as being divided into 2 groups, the dexmedetomidine group(47 cases) and propofol and remifentanil (the control group, 44 cases). Patients in the control group were infused with propofol injection and remifentanil injection. Pa?tients in dexmedetomidine group were infused with dexmedetomidine injection (0.5 μg/kg) 15 minutes before an?esthesia induction and then given the maintenance dose of dexmedetomidine injection 0.2 μg·kg-1·h-1 until 40 minutes before the end of operation. Systolic blood pressure (SBP) , diastolic blood pressure (DBP) and heart rate (HR) were recorded before administration, at intubation, at extubation, and 30 min after extubation. Dosages of profol, fentanyl and dexmedetomidine injection, and incidences of perioperative adverse reactions were ob?served in both groups. VAS score was compared between the two groups 30 min after operation. Results The usage amount of propofol (0.08±0.01) mg·kg-1·min-1 and fentanyl (0.07±0.02)μg·kg-1·min-1 injection in dexme?detomidine group were lower than those of the control group (0.10 ± 0.02) mg·kg-1·min-1 and (0.13 ± 0.02) μg· kg-1·min-1 (P＜0.01). The incidences of extubation cough, nausea, vomiting and shivering (4.26%) and postoper?ative VAS score (1.45±0.03) in dexmedetomidine group were lower than those of the control group(40.91%) and (3.80±0.30) (P＜0.01). SBP, DBP and HR in dexmedetomidine group were lower than those of the control group (P＜0.05). Conclusion Dexmedetomidine injection can relieve intraoperative stress response, maintain circu?lation stability, reduce anesthetic usage, and decrease the incidence of perioperative adverse reactions in acute abdominal diseases.关键词
急腹症/右美托咪啶/丙泊酚/瑞芬太尼Key words
Acute abdominal syndrome/dexmedetomidine/propofol/remifentanil分类
医药卫生引用本文复制引用
章静,宋凯,徐家济,余剑波..右美托咪啶在急腹症手术中的应用[J].中国中西医结合外科杂志,2016,22(2):146-149,4.
