针灸临床杂志2016，Vol.32Issue(1)：72-75,4.
针刀疗法对腰椎间盘突出症大鼠背根神经节局部微循环影响的实验研究
Effect of Acupotomy on Local Microcirculation of Dorsal Root Ganglion in Rats with Lumbar Disc Herniation
摘要
Abstract
Objective:To observe the effect of acupotomy on the changes of blood flow of dorsal root ganglion in L5 and TXB2 and 6-K-PGF1αin plasma of rats with radicular pain of lumbar disc herniation ,so as to explore possible mechanism of acupotomy .Methods:32 male SD rats were randomly divided into a blank group ,a model group ,an acupotomy group and an electroacupuncture group ,with 8 rats in each group .On the eighth day after modeling ,laser doppler flowmeter was taken to record the dynamic graph of blood flow of the dorsal root gangli-on( DRG) in L5 , and the plasma was taken to observe the changes of TXB 2 and 6-K-PGF1αby ELISA.Re-sults:The comparison of the blood flow of dorsal root ganglion among each group was that the model group (46. 56 ±10 .64 ) decreased significantly ( P<0 .01 ) compared with the blank group ( 77 .13 ±20.56 ) ;acupotomy group (70.56 ±19.84) decreased compared with the model group (46.56 ±10.64)(P<0.05) .The compari-son of the ratio of TXB2 and 6-K-PGF1αamong each group was that the model group (1.89 ±0.30)in plasma increased significantly (P<0.01) compared with the blank group (0.77 ±0.19);acupotomy group(1.07 ±0. 18)decreased compared with the model group (1.89 ±0.30) (P<0.01).Conclusion:Acupotomy therapy can improve the local microcirculation of dorsal root ganglion in rats with lumbar disc herniation ,and it may be by regulating the balance of TXB 2 and 6-K-PGF1αto achieve.关键词
针刀疗法/腰椎间盘突出症/背根神经节/微循环/血栓素B2/6-酮-前列腺素F1αKey words
Acupotomy/Lumbar disc herniation/DRG/Microcirculation/TXB2/6-K-PGF1α分类
医药卫生引用本文复制引用
王美琴,郭长青,张义,张伟夫,何智菲,于佳妮..针刀疗法对腰椎间盘突出症大鼠背根神经节局部微循环影响的实验研究[J].针灸临床杂志,2016,32(1):72-75,4.基金项目
北京中医药大学自主课题项目，编号2014JYBZZXS043。 （）
