肿瘤药学2016，Vol.6Issue(1)：26-30,5.DOI:10.3969/j.issn.2095-1264.2016.01.06
细胞外基质、基质金属蛋白酶与恶性肿瘤关系的研究进展
The Research Progress of Relationship between ECM, MMPs and Malignant Tumor
胡梅艳 1孙晓红2
作者信息
- 1. 南华大学研究生院，湖南 衡阳，421000
- 2. 南华大学附属南华医院，湖南 衡阳，421000
- 折叠
摘要
Abstract
Invasion and metastasis of tumor cells became critical factors in the prognosis of malignant tumors. In preventing tumor metastasis, extracellular matrix played an important role as a barrier. Its main components, fibronectin and laminin, were con-nected to the cell surface membrane protein receptor, determining the shape of the cells and controlling the cell differentiation and migration. Therefore, the degradation of extracellular matrix and break of basement membrane created adequate condition for tumor cells invasion and metastasis. While matrix metalloproteinases were the most important protein enzymes of degradation of extracel-lular matrix, involved in multiple steps of tumorigenesis, invasion and metastasis. In this article, we mainly summarized the research progress of the extracellular matrix, matrix metalloproteinases and invasion and metastasis of malignant tumor.关键词
细胞外基质/基质金属蛋白酶/血管新生/恶性肿瘤Key words
ECM/MMPs/Angiogenesis/Malignanttumor分类
医药卫生引用本文复制引用
胡梅艳,孙晓红..细胞外基质、基质金属蛋白酶与恶性肿瘤关系的研究进展[J].肿瘤药学,2016,6(1):26-30,5.
