肿瘤药学2016，Vol.6Issue(1)：44-48,5.DOI:10.3969/j.issn.2095-1264.2016.01.10
PD-1、PD-L1蛋白在外周T细胞淋巴瘤中的表达及其与预后的关系
The PD-1 and PD-L1 Protein Expression in Peripheral T cell Lymphoma and Their Correlation with Prognosis
摘要
Abstract
Objective To investigate the protein expression of programmed cell death-1 (PD-1) and programmed death ligand 1 (PD-L1) in the tissues of peripheral T-cell lymphoma (PTCL), and to analyze the relationship between its expression, chemotherapeu-tic effect and prognosis. Methods The expressions of PD-1 and PD-L1 protein in tumor tissue of PTCL were detected by immunohis tochemistry. The correlation between the protein expressions, clinical stages and prognosis was evaluated. Results In tumor tissues of PTCL patients, the expression rate of PD-1 protein was 35﹪, while the expression rate of PD-L1 was 70﹪. In the normal inflamma-tory lymph nodes, the expression of PD-L1 and PD-1 were not found. The expressions of PD-1 and PD-L1 were positively correlated with clinical stages. The expression of PD-1 was negatively correlated with curative effect. Survival rate was significantly lower in the patients with PD-L1 and PD-1 co-expression. Conclusion The expression rates of PD-1 and PD-L1 protein in lymphoma tissues of PTCL patients were higher than in normal inflammatory lymph nodes, and they may be the potential indicators of poor prognosis.关键词
外周T细胞淋巴瘤(PTCL)/程序性细胞死亡受体1(PD-1)/程序性细胞死亡受体1配体(PDL-1)/预后Key words
PeripheralTcelllymphoma(PTCL)/PD-1/PD-L1/Prognosis分类
医药卫生引用本文复制引用
吕学文,徐琼,陈焕伟,王博,张茜..PD-1、PD-L1蛋白在外周T细胞淋巴瘤中的表达及其与预后的关系[J].肿瘤药学,2016,6(1):44-48,5.基金项目
广东省医学科学技术研究基金项目（B2015039）。 （）
