动物医学进展2016，Vol.37Issue(4)：104-109,110,7.
药动／药效同步模型在兽用抗菌药物研究的应用概况
Progress on Pharmacokinetic/pharmacodynamic Modeling of Antimicrobial Drugs Used in Veterinary Medicine
摘要
Abstract
Pharmacokinetic/pharmacodynamic modeling (PK/PD modeling)is a kind of whole model which links pharmacokinetics and pharmacodynamics,and describes the change of pharmacological effects with time.PK/PD modeling has been widely used in studies of pharmacology and toxicology,clinical medication, new drug evaluation and other fields.With the development of antimicrobials,the issue of antimicrobial re-sistance has become a focus of global concern.PK/PD modeling has been used in the veterinary medicine research,not only can optimize dosage regimens for reducing bacterial resistance,but also can provide re-search basis for developing new drugs.This review summarized the classification of veterinary antimicrobi-als,the research methods of PK/PD model and its applications in veterinary medicine,which could provide a reference for the application of PK/PD modeling in clinic.关键词
药动/药效同步模型/抗菌药物/应用Key words
pharmacokinetic/pharmacodynamic model/antimicrobial/application分类
农业科技引用本文复制引用
周巧仪,张桂君,方炳虎..药动／药效同步模型在兽用抗菌药物研究的应用概况[J].动物医学进展,2016,37(4):104-109,110,7.基金项目
国家自然科学基金项目 （）
