南方医科大学学报2016，Vol.36Issue(4)：532-537,6.
Slug、ZEB1和KISS-1在胃腺癌中的表达及其临床意义
Expressions of Slug, ZEB1 and KISS-1 in gastric adenocarcinoma and their clinical significance
摘要
Abstract
Objective To identify potential markers for predicting invasion, metastasis, and prognosis of gastric adenocarcinoma (GAC). Methods The expressions of Slug, ZEB1 and KISS-1 were detected immunohistochemically in 261 GAC tissues and 80 normal gastric tissues. Results The positivity rates of Slug, ZEB1, and KISS-1 in gastric tissues were 2.5%, 1.3%, and 87.5%, respectively, significantly different from the rates of 62.1%, 28.4%, and 41.1% in GAC tissues (P<0.05). The expression level of Slug was significantly correlated with the depth of invasion, lymph node metastasis, and pTNM stages;the positivity rates of both ZEB1 and KISS-1 were significantly correlated with the tumor grade, depth of invasion, lymph node metastasis and pTNM stages. Slug expression was positively correlated with ZEB1 expression, and KISS-1 expression was inversely correlated with Slug and ZEB1 expressions. Kaplan-Meier analysis showed that the overall survival time of patients with positive expressions of Slug and ZEB1 was significantly shorter than that of the negative patients, and the survival time of patients positive for KISS-1 was significantly longer than the negative patients. COX multivariate analysis showed that positive Slug, ZEB1 and KISS-1 protein expressions and pTNM stages were independent prognostic factors of GAC (P<0.05). Conclusion The abnormal expressions of Slug, ZEB1 and KISS-1 may contribute to the tumorigenesis of GAC and are related with lymph node metastasis, pTNM stages, and prognosis of GAC. The combined detection of Slug, ZEB1, and KISS-1 expression has an important value in predicting the progression and prognosis of GAC.关键词
胃肿瘤/Slug/ZEB1/KISS-1/预后Key words
gastric neoplasm/Slug/ZEB1/KISS-1/prognosis引用本文复制引用
周蕾,胡永莲,武世伍,俞岚,承泽农,朱博..Slug、ZEB1和KISS-1在胃腺癌中的表达及其临床意义[J].南方医科大学学报,2016,36(4):532-537,6.基金项目
2015年院级大学生创新创业训练项目（201510367012）；安徽省高等学校自然科学研究项重点目（KJ2015A269）；安徽省高等学校优秀青年人才重点项目（gxyqZD2016160）；2016年度安徽高校自然科学研究项目重点项目 （）
