湖南中医药大学学报2016，Vol.36Issue(4)：11-14,4.DOI:10.3969/j.issn.1674-070X.2016.04.003
止痛健骨方对兔膝骨关节炎模型滑膜及软骨修复的影响
Effects of Zhitong Jiangu Decoction on Synovial and Cartilage Repair in Rabbit Models of Knee Oosteoarthritis
摘要
Abstract
Objective To observe the effect of Zhitong Jiangu decoction on synovial and cartilage repair in rabbit models of knee osteoarthritis. Methods The rabbits were randomly divided into normal control group, model control group, Gucining group, and low, medium and high dose of Zhitong Jiangu groups, six rabbits in each group, after rabbit models of knee osteoarthritis were successfully established. Rabbits of low, middle, high dose of Zhitong Jiangu were given 4.48, 8.96 17.92 g/kg Zhitong Jiangu decoction, respectively. Gucining group was given 0.504 g/kg Gucining capsule, while normal control group and model control group were given 10 mL/kg distilled water for once per day, continuously administration for 4 weeks. Then right knee flexion mobility, synovium thickness and ratio of noncalcified cartilage with calcified, and synovial fluid inflammatory cells were observed and compared. Results After 4 weeks, compared with normal control group, the right knee flexion mobility and ratio of noncalcified cartilage with calcified of the model control group was decreased, while its synovium thickness and synovial fluid inflammatory cells was increased (P<0.05). Compared with model control group, the knee flexion mobility and ratio of noncalcified cartilage with calcified of Zhitong JianGu groups were increased, while their synovium thickness and synovial fluid inflammatory cells were decreased, the diffrences were statistically significant (P <0.05). Conclusion Zhitong Jiangu decoction could inhibit the synovium hyperplasia, thicken noncalcified cartilage, delay cartilage degeneration and increase knee flexion mobility, it may be a mechanism for the treatment of knee osteoarthritis.关键词
止痛健骨方/膝骨关节炎/兔/滑膜/软骨/当归/白芥子/丹参Key words
Zhitong Jiangu decoction/knee osteoarthritis/rabbits/synovium/cartilage/Angelica sinensis/mustard/Salvia miltiorrhiza分类
医药卫生引用本文复制引用
苏新平,朱克俭,谭旭仪..止痛健骨方对兔膝骨关节炎模型滑膜及软骨修复的影响[J].湖南中医药大学学报,2016,36(4):11-14,4.基金项目
湖南省中医药科研基金资助项目（2008035）。 （）
