Abstract
Objective:To explore the effects of four kinds of atypical anti-psychotic drugs on the levels of high -sensitivity C-reactive protein and blood lipid in patients with schizophrenia .Methods:115 patients with schizophreni‐a were randomly divided into four groups:Clozapine group(n=29) ,risperidone group(n=29) ,olanzapine group(n=28) ,and aripiprazole group(n=29) .Setting one control group(n=30) .The follow -up examination of each group was performed for 12 weeks .The levels of high-sensitivity C -reactive protein(hs-CRP) ,triglyceride(TG) ,total chole-sterol(TC) ,high-density lipoprotei ,n(HDL) ,low -density lipoprotein(LDL) ,apolipoproteinA1(APoA1) , apolipoproteinB(APoB)were measured before and after the treatment course ,respectively .The waist circumference , height and weight were also measured to evaluate the body mass index(BMI) .Results:① After 12 weeks ,the levels of hs-CRP(t=‐3 5.12 ,‐21 2.72 ,‐3 3.64) ,TG(t=‐3 4.31 ,‐3 4.42 ,‐3 7.66) ,TC(t=‐3 2.60 ,‐17 3.95 ,‐17 6.26) ,HDL(t=7 6.34 ,10 9.32 ,8 6.27) ,LDL(t=‐3 9.10 ,‐4 3.39 ,‐4 2.74) ,BMI(t=‐69 5.70 ,‐33 2.04 ,‐60 6.10)in clozapine group ,risperi‐done group and olanzapine group ,showed clear differences(P<0 0.5) ,compared with those before tre-atment .The levels of ApoB in olanzapine group were obviously different compared with that before treatment(t=‐3 .173 P<0 0.5) .The levels of TC(t=‐18 9.74) ,LDL(t=‐3 2.30) ,BMI(t=‐4 7.43)in aripiprazole group were obviously different compared with that before treatment(P< 0 .05) .There was no significant difference in each figure of the control group(P>0 0.5) .② After 12 weeks ,the levers of hs-CRP in clozapine group and olanzapine group were higher than other groups(P<0 0.5) .The levels of TC ,HDL in clozapine group ,risperidone group and olanzapine group increased significantly(P<0 0.5) .The levels of BMI in clozapine group was significantly higher than those in the other groups (P<0 0.5) .Conclusion:The levels of high -sensitivity C -reactive protein ,blood lipid and body mass index in pa‐tients with schizophrenia are increased by the three factors(clozapine ,risperidone ,olanzapine) .The risk of cardiovas‐cular disease may also significantly increased in the future .关键词
非典型抗精神病药/超敏C反应蛋白/血脂/精神分裂症Key words
Atypical antipsychotic drugs/High-sensitivity C-reactive protein/Blood lipid/Schizophrenia分类
医药卫生
