军事医学2016，Vol.40Issue(4)：304-307,4.DOI:10.7644/j.issn.1674-9960.2016.04.009
高尔基蛋白73参与炎症反应的分子机制研究
Molecular mechanism of Golgi protein 73 in inflammation
摘要
Abstract
Objective To study the effect of Golgi protein 73(GP73) on inflammation, and to reveal the effect of GP73 on tumorigenesis and metastasis.Methods The transcriptional activity of NF-κB and the expression of IL-1β, IL-6 and TNF-αwith GP73 overexpression or knockdown were detected to illuminate the role of GP73 in inflammation.According to the TCGA database, the correlation between the transcriptional activity of GP73 and the expression of NF-κB, IL-1β, IL-6 and TNF-αwas analyzed to determine the role of GP73 in tumor inflammation.Results Correlative analysis showed that there was a positive correlation between the expression of GP73 with NF-κB, IL-1β, IL-6 and TNF-α.The transcriptional activity of NF-κB was upregulated by GP73 overexpression, but downregulated by GP73 knockdown.The expression of IL-1β, IL-6 and TNF-αwas upregulated by GP73 overexpression.Ammonium pyrrolidinedithiocarbamate ( PDTC ) was in-volved in inflammation reaction induced by GP73.Conclusion GP73 is possibly involved in inflammation and promotes tu-morigenesis and metastasis.关键词
GP73/肿瘤/炎症/NF-κB/白细胞介素/肿瘤坏死因子αKey words
GP73/neoplasm/inflammation/NF-κB/interleukin/tumor necrosis factorα分类
医药卫生引用本文复制引用
王翠,魏从文,邹德勇,刘丽萍,郝钦芳,丁琪,钟辉,杨晓莉..高尔基蛋白73参与炎症反应的分子机制研究[J].军事医学,2016,40(4):304-307,4.基金项目
武警部队院级二类课题资助项目 （）
