中国伤残医学2016，Vol.24Issue(8)：12-14,3.DOI:10.13214/j.cnki.cjotadm.2016.08.006
鸟氨酸脱羧酶和c－myc在胃癌及其癌前病变组织中的表达及意义
Expression of ornithine decarboxylase and c-myc in gastric cancer and premalignant lesions and its significance
魏小娟 1王云溪1
作者信息
- 1. 新乡市中心医院消化内科，河南新乡 453600
- 折叠
摘要
Abstract
Objective:To detect the expression of ODC and c-myc in chronic superficial gastritis, intestinal metaplasia, atypical hy-perplasia and gastric carcinoma, to explore the correlation and significance of the expression of ODC and c-myc in gastric carcinoma and precancerous lesions.Methods:The expressions of ODC and c-myc were detected by RT-PCR and immunohistochemistry in 18 cases of chronic superficial gastritis( CSG) , 18 chronic atrophic gastritis with intestinal metaplasia CAG( with IM) ,12 gastric dysplasia ( DYS) and 30 gastric carcinoma ( GC) , to explore the correlation between ODC and c-myc and their relationship with precancerous gastric le-sions.Results:The expression of ODC in CAG with IM, DYS and GC was significantly higher than that in CSG(P<0.01).The expres-sion of c-myc was significantly higher in GC comparing with CSG and CAG with IM (P<0.01).In addition, ODC and c-myc positive immunostaining rates were significantly higher in poorly-differentiated GC than in well-differentiated GC (P<0.01).The expression of ODC was positively correlated with c-myc at different stages of gastric carcinogenesis.Conclusions:ODC may play an important role as carcinogenic factor, and c-myc promotes cell proliferation by inducing ODC expression.Detecting both markers together may help in ear-ly diagnosis of gastric carcinoma.关键词
鸟氨酸脱羧酶/c-myc/癌前病变/逆转录聚合酶链反应/免疫组织化学Key words
ODC/C-myc/Precancerous lesions/RT-PCR/Immunohistochemical method分类
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魏小娟,王云溪..鸟氨酸脱羧酶和c－myc在胃癌及其癌前病变组织中的表达及意义[J].中国伤残医学,2016,24(8):12-14,3.
